风险评估:最近在确定足够相似性的进展
Julia E Rager1,2, Cynthia V Rider3
1The Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill.
Current opinion in toxicology
|October 4, 2023
概括
评估复杂混合物对人类健康的风险需要比较暴露. 本综述探讨了确定混合物相似性的方法,这在没有准确的暴露数据的情况下至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 风险评估 风险评估
背景情况:
- 人类健康风险评估通常涉及复杂的化学混合物.
- 首选的是全混合方法,但经常缺乏准确的暴露数据.
- 来自类似混合物的替代数据通常是必要的风险评估.
研究的目的:
- 审查最近在确定整体复杂混合物的足够相似性的进展.
- 突出比较化学特征,生物活性和统计评估的工具和方法.
- 确定混合物相似性评估的局限性,并为最佳实践提供建议.
主要方法:
- 关于混合物相似性的最新科学文献的综述.
- 分析用于比较化学成分,生物活性资料和统计数据的方法.
- 审查涉及水消毒副产品,植物成分和野火排放的案例研究.
主要成果:
- 开发用于比较复杂混合物的"相似度值".
- 使用各种案例研究来展示工具和方法.
- 在基于风险的决策中应用相似性评估的局限性.
结论:
- 在确定混合物相似性的进步对于现实世界的风险评估至关重要.
- 需要标准化的方法和指导方针,以便在基于风险的决策中应用足够的相似性.
- 未来的工作重点应该是制定混合物评估的最佳实践指南.
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