肝转移会影响免疫检查点抑制剂在胃癌单疗期间的进展模式
Iori Motoo1, Takayuki Ando1, Takeru Hamashima2
1Third Department of Internal Medicine, University of Toyama, Toyama, Japan.
Frontiers in oncology
|October 4, 2023
概括
免疫检查点抑制剂 (ICI) 在胃癌 (GC) 患者中表现出不同的疗效. 非系统性进展与更好的生存相关,肝转移可能通过影响CD8+T细胞来预测系统性进展.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃癌研究 胃癌研究
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中在转移部位表现出异质的疗效.
- 瘤进展模式显著影响存活结果,但这在ICI治疗下对于胃癌 (GC) 并未明确.
研究的目的:
- 为了阐明胃癌在ICI反应中的进展模式.
- 调查潜在的机制,专注于内免疫细胞种群.
主要方法:
- 对148名接受ICI治疗的胃癌患者进行了回顾性分析.
- 根据放射学评估,分类为非系统性和系统性进展组.
- 在不同器官的目标病变中最佳百分比变化的比较.
主要成果:
- 与系统性进展相比,非系统性进展与显著改善的整体存活率 (OS) 相关 (中位数为5.6个月与3.3个月).
- 肝转移被确定为系统性进展的预测因素,并显示ICI的反应最差.
- 与没有肝转移的患者相比,肝转移的患者观察到较低的内CD8+T细胞密度.
结论:
- 进展模式与接受ICI的胃癌患者的整体存活率显著相关.
- 肝转移可以作为ICI治疗期间系统性进展的预测生物标志物,可能通过内CD8+T细胞的调节来调节.
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