在高压氧气方面的进步通过调节瘤微环境来促进免疫治疗
Pei Wang1, Xiao-Yan Wang2, Chang-Feng Man1
1Cancer Institute, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Frontiers in oncology
|October 4, 2023
概括
高压氧气疗法可以通过改变瘤微环境来改善癌症免疫疗法. 这种方法针对瘤缺氧,并产生反应性氧物种,提高治疗效率.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物医学工程 生物医学工程
背景情况:
- 高压氧疗法 (HBOT) 是一种安全的临床治疗方法.
- 在癌症中,HBOT增强了放射治疗和光动力疗法.
- 有限的研究存在于HBOT在癌症免疫治疗中的作用.
研究的目的:
- 探索高压氧气疗法如何影响癌症免疫疗法.
- 总结一下HBOT调节瘤微环境的机制.
- 为未来免疫疗法发展提供见解.
主要方法:
- 对有关HBOT和癌症治疗的现有文献的审查.
- 对HBOT对瘤缺氧的影响的分析.
- 研究HBOT对催氧诱导因素和反应性氧物种生成的影响.
主要成果:
- HBOT改善了瘤的氧化,抵消了缺氧.
- HBOT的目标是低氧诱导因素,这是瘤的关键调节者.
- HBOT产生反应性氧物种,影响瘤的微环境.
结论:
- 高压氧气疗法显著调节瘤的微环境.
- 通过HBOT对瘤微环境的调节会影响免疫治疗的结果.
- 在未来的癌症免疫治疗中,HBOT提供了一种有前途的策略.
相关概念视频
Tumor Immunotherapy
551
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
551
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Cancer Vaccines
396
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
396
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
249
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
249


