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相关概念视频

Alternative RNA Splicing02:18

Alternative RNA Splicing

21.2K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.2K
RNA Splicing01:32

RNA Splicing

56.5K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Pre-mRNA Processing: RNA Splicing01:36

Pre-mRNA Processing: RNA Splicing

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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

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相关实验视频

Updated: Jul 15, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

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替代拼接识别方面的进展:深度学习和泛转录组.

Fei Shen1, Chenyang Hu1,2, Xin Huang1

  • 1Institute of Biotechnology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.

Frontiers in plant science
|October 4, 2023
PubMed
概括
此摘要是机器生成的。

植物中的替代拼接通过创建多个mRNA变异产生多样化的蛋白质. 这项研究探讨了先进的算法和深度学习,以准确地识别拼接事件,甚至在泛基因组环境中.

关键词:
在ISO-seqq中使用.在RNA-seqqq.替代性拼接是一种替代性的拼接.深度学习是一种深度学习.检测算法 检测算法翻译 翻译 翻译 翻译

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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
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Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

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相关实验视频

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Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
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Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

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科学领域:

  • 植物分子生物学 植物分子生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 替代拼接是植物中一个关键的转录后基因调节机制.
  • 它产生多样化的mRNA异型和蛋白质,增加功能复杂性.
  • 准确识别拼接事件对于理解基因调节至关重要.

研究的目的:

  • 介绍植物中替代拼接算法的应用,有或没有参考基因组.
  • 突出深度学习的整合,以提高检测准确度.
  • 在泛基因组背景下讨论替代拼接和综合战略.

主要方法:

  • 审查和应用现有的替代拼接算法.
  • 集成深度学习技术,以提高准确性.
  • 在泛基因组框架内的分析.

主要成果:

  • 证明了各种算法用于植物替代拼接检测的实用性.
  • 通过深度学习集成展示了更好的准确性.
  • 强调了泛基因组方法对于全面分析的重要性.

结论:

  • 先进的算法和深度学习显著改善了植物中的替代拼接识别.
  • 全基因组研究和综合策略对于完全了解替代拼接至关重要.