相关的Th17和卡尔格拉努林响应在孕期前期怀孕的母带血二合体中,具有史学性胆膜炎
Christopher Q Buchanan1, Megan L Lawlor1, Chukwuebuka Okafor2
1Department of Obstetrics, Gynecology and Women's Health, Division of Maternal-Fetal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America.
概括
孕产妇和胎儿的Th17免疫反应在早产怀孕中被放大,其中包括组织学肌膜炎 (HCA). 这突显了HCA病原和新生儿结局中的母胎免疫交叉.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖医学 生殖医学
- 新生儿科学 新生儿科学
背景情况:
- 母胎免疫交叉是妊娠障碍的关键,比如组织学肌膜炎 (HCA).
- 在HCA中已知新生儿的Th17免疫表型,但母亲的Th17反应仍然不清楚.
- 了解HCA中的Th17生物学对于完善怀孕并发症的知识至关重要.
研究的目的:
- 为了研究HCA的早产妊娠中母亲和带血的Th17反应.
- 阐明母胎免疫相互作用在HCA病变发生中的作用.
主要方法:
- 从早产妊娠 (23-34周) 与HCA或对照对母体和带血 (CB) 样本的未来采集.
- 流细胞计和酶相关免疫试验用于确定Th17细胞频率和血卡尔格拉努林 (S100A8,S100A12) 水平.
主要成果:
- 在与胎儿炎症的母带血对中观察到的Th17细胞频率和血卡尔格拉努林水平的并行增加.
- 带血S100A12水平与Th17细胞频率正相关.
- 重组人类S100A12 (rh-S100A12) 在带血培养中促进了Th17型CD4+细胞的体外扩张.
结论:
- 孕产妇和带血的Th17相关反应在HCA中被放大,这表明孕产妇与胎儿相互作用的作用.
- 这些发现促进了对新生儿Th17机制的理解,以及它们与HCA中母亲炎症的联系.
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