日本COVID-19患者的肥胖悖论
Junichi Yoshida1, Kaoru Setoguchi1,2, Kenichiro Shiraishi1,3
1Infection Control Committee, Shimonoseki City Hospital, Shimonoseki, Japan.
International journal of medical sciences
|October 4, 2023
概括
在日本COVID-19患者中,体重不足与较低的死亡率和减少对侵入性呼吸系统护理 (IRC) 的需求有关. 超重个体也表现出低风险,突出了COVID-19结果中的肥胖悖论.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 关键护理医学 关键护理医学
背景情况:
- 肥胖是一个已知的COVID-19严重结局的风险因素.
- 身体质量指数 (BMI) 对COVID-19患者的死亡率和呼吸系统支持需求的影响需要进一步调查,特别是在多样化的群体中.
研究的目的:
- 为了检查肥胖和死亡率之间的联系.
- 评估COVID-19患者肥胖和侵入性呼吸系统护理 (IRC) 的要求之间的关系.
主要方法:
- 在34个月的时间里,研究了1,105名COVID-19患者的队列.
- 收集了29天所有原因死亡率和IRC (按氧化参数定义) 的数据.
- 进行了多变量回归分析,根据年龄和性别进行了调整.
主要成果:
- 体重指数 (BMI) 大于19.6kg/m2显著与29天死亡率降低相关 (OR0.117).
- 分析显示,BMI在11到25公斤/米2的范围内,死亡率和IRC率呈下降趋势.
- 超重患者 (BMI 25-29.9 kg/m2) 没有显示增加不良结果的风险.
结论:
- 体重不足的COVID-19患者的死亡率和IRC率下降.
- 超重和中度肥胖的COVID-19患者显示死亡率和IRC持续低风险.
- 这些发现表明,潜在的肥胖悖论影响了研究日本人口的COVID-19严重程度和结果.
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