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精油与抗生素的合作伙伴:已被证明的治疗方法可以预防牛 Staphylococcus aureus 乳腺炎
Marwa I Abd El-Hamid1, Reham M El-Tarabili2, Mosa M Bahnass3,4
1Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Frontiers in cellular and infection microbiology
|October 4, 2023
概括
像林纳醇,卡瓦克罗尔和尤根醇这样的精油显示出对抗多药耐药的金黄色葡萄球菌生物膜的前景. 将这些精油与抗生素结合起来,可能为牛乳腺炎提供新的治疗策略.
科学领域:
- 兽医微生物学 兽医微生物学
- 自然产品化学 自然产品化学
背景情况:
- 生体膜产生的金黄色葡萄球菌 (S. aureus) 是一个重要的治疗挑战,特别是在牛乳腺炎.
- 多药性耐药性 (MDR) 和多病毒性因素加剧了治疗金黄色细菌感染的困难.
研究的目的:
- 评估精油 (EO) 卡瓦克罗尔,林纳醇和尤根醇对黄金菌的抗菌和抗菌膜活性.
- 研究这些EO与常见抗生素结合的协同效应.
- 评估EO作为对抗性黄金色杆菌感染的辅助疗法的潜力.
主要方法:
- 使用表型和基因型方法来表征S. aureus从牛乳腺炎中分离出来的多药耐药性,多病毒性和生物膜生产.
- 在体外抗菌和抗菌膜测试中进行了卡瓦克罗尔,林纳醇和尤根醇的测试.
- 用分子对接研究和棋盘测试来评估EO活性和抗生素-EO相互作用.
主要成果:
- 所有37个金黄色细菌分离物都是产生生物膜的耐甲林的金黄色细菌 (MRSA);40.5%是耐米素的金黄色细菌 (VRSA).
- 林纳醇表现出最强的抗微生物和抗菌膜活性,其次是卡瓦克罗尔和尤根醇.
- 在EO和甲基西林或万科米辛之间观察到协同相互作用 (FICI ≤0.5),其中一些隔离物回归到敏感的表型.
结论:
- 精油,特别是林纳醇,对产生生物膜的,多药耐药的金杆菌具有显著的潜力.
- 将EO与传统抗生素相结合,为克服牛乳腺炎治疗失败提供了一个有希望的策略.
- 基于EO的配方的进一步开发可能会导致针对耐药S. aureus病原体的新药剂.
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