一个范围审查,以评估与焦虑缓解药物相关的骨折风险
Johnathan Dallman1, Levi Aldag1, Amanda Klass1,2
1University of Kansas Medical Center, Kansas City, KS.
抗焦虑药物,如二类药物和ATC类N05B增加骨折的风险,特别是在老年人和特定的性别/年龄组. 然而,一些抗焦虑药可能会降低骨折风险,突出显示不一致的发现.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
- 整形外科 整形外科 整形外科
背景情况:
- 骨折对健康和经济造成重大负担.
- 了解药物对骨折风险的影响对于患者安全至关重要.
- 抗焦虑药物被广泛处方,需要评估它们与骨折风险的关联.
研究的目的:
- 对抗焦虑药物及其与骨折风险增加的潜在关联进行文献审查.
- 综合目前关于抗焦虑药物类与骨折发生率之间的关系的研究.
主要方法:
- 在2021年7月之前,对MEDLINE和Embase数据库进行了系统搜索.
- 包括的研究集中在那些接受过抗焦虑药物处方 (ATC类 N05B,β-阻断剂,皮) 的患者身上,这些患者患有骨折.
- 搜索术语是"精神药物"和"骨折"的组合变体,使用MeSH术语.
主要成果:
- 在3,213项研究中,有13项符合纳入标准.
- 二类药物与骨折有关,60岁以上患者的风险最高 (RR=2.29).
- 在55岁以下的男性 (RR=5.42) 和女性 (RR=3.33) 中,ATC类N05B的骨折风险增加. 佐尔比在前四周增加了风险 (RR=2.29),而β抑制剂显示风险降低 (RR=0.77).
结论:
- 抗焦虑药物,特别是二类药物和ATC类N05B,在特定人群中与骨折风险增加有关.
- 调查结果表明,抗焦虑药物的骨折风险评估存在不一致,一些药物可能会降低风险.
- 需要进一步的研究来澄清抗焦虑药和骨折风险之间的复杂关系.
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