喘和COVID-19结果:在一个大型医疗保健服务系统中的前性研究
Lindsay K Finkas1, Navneet Ramesh2, Lawrence S Block3
1Kaiser Permanente San Rafael Medical Center, San Rafael, CA, USA.
Journal of asthma and allergy
|October 4, 2023
概括
喘患者在Omicron期间感染COVID-19的风险较低,但在Delta变种出现之前,住院的风险更高. 严重的喘和女性性增加了住院的风险.
科学领域:
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
背景情况:
- 关于喘对COVID-19结果的影响存在不一致的发现.
- 了解这种关联对于在疫情期间管理患者至关重要.
研究的目的:
- 为了调查喘和COVID-19结果之间的关联.
- 为了比较不同流行病阶段的喘患者与对照者的感染,住院和ICU入院率.
主要方法:
- 一项前性研究涉及41,282名喘患者和匹配的对照.
- 从电子健康记录中收集的数据跨越了Delta,Delta和Omicron变种前的时间.
- 分析的结果包括COVID-19感染,住院和ICU入院,根据人口统计,并发病症和疫苗接种情况进行调整.
主要成果:
- 喘患者更有可能接受COVID-19检测.
- 在Omicron期间 (OR=0.92) 的喘患者中观察到COVID-19感染的风险较低.
- 在三角洲前期,人们注意到COVID-19住院 (HR=1.33) 和ICU入院的风险增加,特别是在严重的喘和女性.
结论:
- 喘与Omicron期间COVID-19感染风险降低有关.
- 喘独立增加了COVID-19在Delta前阶段住院的风险,特别是严重病例和妇女.
- 疫苗接种状态并没有显著改变这些关联.
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