代谢功能障碍相关的脂肪肝疾病和非酒精性脂肪肝疾病之间的结果比较:元分析
Ghazala S Virk1, Jaahnavi Vajje2, Nausheen K Virk3
1Internal Medicine, Avalon University School of Medicine, Youngstown, USA.
Cureus
|October 4, 2023
概括
与非酒精性脂肪性肝病 (NAFLD) 患者相比,与代谢功能障碍相关的脂肪性肝病 (MAFLD) 患者的心血管死亡和全因死亡风险更高. 这一元分析强调MAFLD是心血管不良结果的重要风险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一系列的肝病.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个拟议的术语,以更好地反映代谢的基础.
- 不断发展的研究需要对NAFLD和MAFLD进行比较.
研究的目的:
- 为了比较MAFLD和NAFLD患者之间的心血管事件和全因死亡率.
- 评估与MAFLD与NAFLD相关的差异性风险.
- 为临床重新分类和风险分层提供证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在PubMed,EMBASE和Web of Science中搜索到2023年7月31日之前的相关研究.
- 包括11项比较MAFLD和NAFLD心血管结果的研究.
主要成果:
- 在MAFLD患者中,心血管死亡率显著增加 (RR: 1.48,95% CI: 1.11-1.98).
- 在MAFLD患者中,所有死因的死亡风险在统计学上显著增加 (RR: 2.80,95% CI: 2.39-3.28).
- 在MAFLD患者中,心血管事件的风险更高 (RR:1.18,95% CI:0.86-1.61).
结论:
- MAFLD诊断与所有原因死亡率和心血管死亡率的风险大幅增加有关.
- 与NAFLD患者相比,MAFLD患者面临更大的心血管事件风险.
- 这些发现支持区分MAFLD和NAFLD在风险评估中的临床意义.
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