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Updated: Jul 15, 2025

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In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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评估炎症的非侵入性方法
I Fine1, A Kaminsky1, L Shenkman1
1Elfi-Tech Ltd., 2 Prof. Bergman St., Science Park, 76705 Rehovot, Israel.
Biomedical optics express
|October 4, 2023
概括
使用新型动态光散射 (DLS) 装置进行红细胞聚合的非侵入性测量显示了诊断炎症状况的潜力. 这种方法可以准确地区分健康人群和患有COVID-19或其他炎症性疾病的患者.
科学领域:
- 生物医学工程 生物医学工程
- 医学诊断 医学诊断 医学诊断
- 血液学 血液学 血液学
背景情况:
- 红细胞聚合的增加与炎症过程的增加有关.
- 目前用于炎症的诊断方法可能具有侵入性或缺乏特异性.
- 需要使用非侵入性技术来评估红细胞 (RBC) 的行为.
研究的目的:
- 研究一种非侵入性动态光散射 (DLS) 方法在体内测量红细胞聚合的潜力.
- 评估红细胞聚合水平与炎症状况之间的相关性.
- 评估开发的mDLS传感器模块在区分患者群体中的有效性.
主要方法:
- 使用VCSEL和光二极管的传感器模块 (mDLS) 的开发,放置在手指袖口上.
- 血流的暂时阻塞使用过度静脉缩袖口膨胀.
- 在控制血流封闭期间记录传感器信号,COVID-19和炎症性疾病患者群体.
主要成果:
- 在对照组和患者组之间观察到信号动态行为的显著差异.
- 这些差异归因于红细胞聚合率的不同.
- 通过mDLS方法,可以根据红细胞聚合模式区分炎症状态.
结论:
- 使用mDLS技术,可以进行红细胞聚合的非侵入性测量.
- 通过mDLS测量红细胞聚合动态,可以作为炎症过程的生物标志物.
- 这项技术有望开发新的非侵入性炎症诊断工具.
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