通过导管进行单输入偏振敏感光学连贯性断层扫描
Georgia L Jones1,2, Qiaozhou Xiong3, Xinyu Liu4,5
1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Biomedical optics express
|October 4, 2023
概括
一种新的信号处理方法简化了用于血管内成像的偏振敏感光学连贯断层扫描 (PS-OCT). 这种技术可以使用简化的硬件对冠状动脉疾病进行准确的评估,从而改善临床翻译.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 心血管研究研究心血管研究
背景情况:
- 极化敏感光学连贯断层扫描 (PS-OCT) 增强了具有形态对比度的结构成像.
- PS-OCT的临床应用受到极度测量所需的硬件修改的阻碍.
研究的目的:
- 开发一种用于PS-OCT的信号处理方法,该方法可以使用单个输入偏振状态重建组织偏振特性.
- 为了简化静脉内PS-OCT的硬件要求,促进临床翻译.
主要方法:
- 一种新的信号处理方法,在往返测量中利用极化对称.
- 采用事件极化状态的剩余光谱变化来解决模两可.
- 从in-vivo人类冠状动脉数据重建深度分辨率的双折射和光轴定向图.
主要成果:
- 证明了对双折射和光轴定向图的准确重建.
- 对传统的双输入状态测量方法进行了验证,显示平均累积阻抗误差为13.2度.
- 对于深度分辨率双断率 (2.80 × 10−4) 达到了95%的一致度,与传统PS-OCT重复拉回 (3.14 × 10−4) 相比.
结论:
- 开发的信号处理方法有效地使用单个输入状态重建偏振特性,简化了PS-OCT硬件.
- 这种简化对于PS-OCT在评估冠状动脉样硬化的临床采用至关重要.
- 该方法显示出高精度和一致性,使其与传统的PS-OCT技术可互换.
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