科尔奇辛对成年人代谢综合征肠道微生物群的影响
Celine M Kisimba1, Jack L Donahue1, Krishna Karthik Chivukula1
1Section on Growth and Obesity, Division of Intramural Research (DIR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), 10 Center Drive, Room 1-3330 MSC 1103 Bethesda, MD 20892, USA.
Bioscience of microbiota, food and health
|October 4, 2023
概括
科尔奇辛在患有代谢综合征的肥胖成年人中减少了全身炎症. 然而,这种抗炎作用在这个肥胖研究中并没有显著改变肠道微生物多样性.
科学领域:
- 代谢健康 代谢健康
- 微生物组研究 微生物组研究
- 炎症生物学 炎症生物学
背景情况:
- 肥胖相关的炎症是胰岛素抵抗和2型糖尿病的关键驱动因素.
- 肥胖的肠道失调有助于代谢功能障碍和全身炎症.
- 肥胖时系统性炎症失调对肠道微生物群的影响尚不清楚.
研究的目的:
- 为了调查胆固醇在肥胖成年人中具有代谢综合征的全身抗炎作用是否与肠道微生物多样性的改善有关.
- 探索系统性炎症标志物和肠道微生物组合之间的关系,在肥胖人群中接受菌素治疗后.
主要方法:
- 一项随机,双盲,安慰剂对照试验的二次分析,涉及40名肥胖,高CRP,胰岛素抵抗和代谢综合征的成年人.
- 参与者接受了 (0.6毫克每天两次) 或安慰剂三个月.
- 从便DNA分析了肠道微生物组成,使用16SrRNA测序;测量了血清中的全身炎症标志物.
主要成果:
- 与安慰剂相比,素显著降低了血清高灵敏性C反应蛋白 (hsCRP),素-6,抵抗素,白细胞计数和中性粒细胞.
- 在胆固醇和安慰剂组之间没有观察到肠道微生物组α多样性的显著变化 (Chao1,Shannon,Pielou指数).
- 菌群和家族层面的微生物组合保持不变;只有*Oscillibacter*属显示了名义上的变化.
结论:
- 科尔奇辛在肥胖和代谢综合征的成年人中有效改善了全身炎症.
- 观察到的胆固醇的全身抗炎作用与肠道微生物群多样性或组成的显著变化无关.
- 需要进一步的研究来阐明系统性炎症和肥胖中的肠道微生物群之间的复杂相互作用.
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