饮食生物标志物 - - 关于它们在流行病学研究中的有效性和适用性的最新信息
Rikard Landberg1, Prasoona Karra2,3, Rachel Hoobler2,3
1Division of Food and Nutrition Science, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Nutrition reviews
|October 4, 2023
概括
本综述确定了有希望的饮食生物标志物,用于跟踪西方饮食在大型研究中的食物摄入量. 虽然有许多候选存在,但需要进一步验证以获得准确的营养流行病学.
科学领域:
- 营养流行病学 营养流行病学
- 生物标志物开发 生物标志物开发
- 饮食评估 饮食评估
背景情况:
- 准确的饮食评估对于营养流行病学至关重要.
- 很少有饮食生物标记候选物被完全验证用于流行病学研究.
- 西方饮食包括各种食物组,对健康有重大影响.
研究的目的:
- 对关键西方饮食食品的饮食生物标志物的有效性和适用性进行审查和总结.
- 确定有希望的生物标志物候选者用于流行病学研究.
- 为充分验证饮食生物标志物突出研究差距.
主要方法:
- 文献搜索集中在之前报告的重要食品组的生物标志物候选者上.
- 用预定义的标准对流行病学研究进行调整,评估生物标志物的有效性.
- 总结研究结果并确定排名最高的生物标志物候选者.
主要成果:
- 在酒精,谷物,咖啡,乳制品,脂肪,水果,豆类,肉类,海鲜,糖,茶和蔬菜中确定了生物标记候选物.
- 有前途的候选物是特定于食物的,具有定义的母化合物,并且不受非食物因素的影响.
- 与习惯摄入量的相关性是中度到强度,但可重现性不同 (低到高);关键数据往往缺失.
结论:
- 为流行病学用途确定了几种西方饮食食品的有前途的饮食生物标志物候选者.
- 进一步的研究是必要的,以解决剂量响应,习惯性摄入相关性和可重现性的数据缺口.
- 开发结合生物标志物和自我报告数据的方法将推动营养流行病学.
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