在固体瘤中使用氧化声动力疗法,加载有聚烯的甲甲基MXene
E Pang1, Baoling Li1, Chuanling Zhou1
1Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P. R. China. minhuanlan@csu.edu.cn.
Nanoscale
|October 4, 2023
概括
这项研究引入了一种新的声敏化剂 (PT2) 和碳化物 (Nb2C) MXene组合,用于在声动疗 (SDT) 中克服瘤缺氧. 这种方法提高了氧气水平,促进了SDT.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 声动力疗法 (SDT) 显示出对固体瘤的希望,这是由于深层组织的透和最小的副作用.
- 然而,瘤缺氧限制了SDT的依赖氧气的疗效.
- 需要新的策略来提高SDT在低氧瘤微环境中的有效性.
研究的目的:
- 开发一种新的纳米平台,将声敏剂 (PT2) 与碳化物 (Nb2C) MXene相结合,以解决瘤缺氧问题.
- 为了研究这个纳米平台的潜力,以缓解缺氧和改善SDT对固体瘤的疗效.
主要方法:
- 合成基于聚提奥芬的声敏化剂 (PT2) 和2D Nb2C MXene.
- 在PVP涂层的Nb2C MXene上加载PT2,形成Nb2C-PVP-PT2纳米薄膜 (NS).
- 评估Nb2C的催化酶类活性,用于氧气生成和PT2的声动力学效应.
主要成果:
- Nb2C MXene表现出类似触酶的活性,将H2O2转化为O2,从而缓解瘤缺氧.
- 在超声波照射下,纳米平台有效地产生单片氧和超氧化离子.
- 观察到抑制瘤细胞DNA复制和诱导细胞死亡,增强SDT的疗效.
结论:
- 开发的Nb2C-PVP-PT2 NSs通过产生氧气有效地对抗瘤缺氧.
- 这一策略通过提高声敏剂的性能和诱导瘤细胞死亡,显著提高了声动力学治疗的疗效.
- 这种组合代表了通过SDT改善固体瘤治疗的有希望的方法.
更多相关视频
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.2K
09:51One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
10.9K
相关概念视频
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:46Electron Transport Chain: Complex I and II
14.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.3K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K