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Updated: Jul 15, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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从结合模块到基本的催化活动:大自然是如何偶然发现一件好事的

Claudèle Lemay-St-Denis1,2,3, Joelle N Pelletier1,2,3,4

  • 1PROTEO, The Québec Network for Research on Protein, Function, Engineering and Applications, Quebec, QC, Canada.

Chemical communications (Cambridge, England)
|October 4, 2023
PubMed
概括

一种简单的蛋白质折叠,一种SH3结合模块,出乎意料地充当了二叶酸还原酶的功能. 它的四重化形成了一个活跃的部位,其中骨干相互作用,而不是特定的残留物,驱动了必要的代谢反应的催化.

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