停止饮食后,持续的高血症模仿低酸盐症:一个病例报告
Sabitha Sasidharan Pillai1,2, Renee Robilliard1,2, Meghan E Fredette1,2
1Division of Pediatric Endocrinology, Hasbro Children's Hospital, Providence, USA.
Journal of pediatric endocrinology & metabolism : JPEM
|October 4, 2023
概括
基因饮食 (KD) 导致的高血症在停止饮食后可能会持续很长时间. 低性酸酶在和PTH之前正常化,表明从KD诱导的骨不活性中恢复.
科学领域:
- 儿科神经学 儿科神经学
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 高血症是基因饮食 (KD) 的不常见并发症.
- 在KD停止后,很少报告长时间的高血症.
- 这一案例突出显示了在一个小孩的后饮食中持续存在的高血症.
研究的目的:
- 在停止饮后报告一个幼儿持续高血症的病例.
- 描述长期高血症的临床过程和实验室发现.
- 讨论对性饮食患者管理的影响.
主要方法:
- 一个2岁,11个月大的孩子在全球发育迟缓和难以治疗的发作时,正在服用素饮食和托皮拉.
- 患者呈现高血症,高血症,急性功能衰竭和低性酸酶.
- 在停止基因饮食和托皮拉后,高血症仍然存在;治疗包括素,水分和低配方.
主要成果:
- 患者的高血症在停止饮食后持续了2个月.
- 实验室参数模仿了低性酸酶和抑制副甲状腺激素 (PTH) 的低性酸酶.
- 性酸酶的正常化先于和PTH的正常化,表明从无动态骨状态的恢复.
结论:
- 过血症可能在停止饮食 (KD) 后持续很长一段时间.
- 实验室发现可能类似于hypophosphatasia.
- 性酸酶的正常化是从KD诱导的骨动态状态恢复的关键指标.
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