在治疗甲状腺眼病的teprotumumab治疗后,proptosis回归
Tatiana R Rosenblatt1, Carolina A Chiou, Michael K Yoon
1Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, U.S.A.
Ophthalmic plastic and reconstructive surgery
|October 4, 2023
概括
采用teprotumumab治疗往往会导致proptosis回归,但有些患者会随着时间的推移而恶化. 大多数患者与基线相比保持了降低的质,尽管在治疗后出现了一些回归.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺眼病 (TED) 是一种影响眼的自身免疫性疾病.
- 眼,或凸起的眼睛,是TED的一个常见的和视觉上有影响力的症状.
- 德鲁马布是一种新的生物疗法,针对TED治疗的IGF-1R途径.
研究的目的:
- 为了分析teprotumumab治疗后的proptosis回归的程度和时间.
- 为了评估在teprotumumab治疗后的长期变化的proptosis.
主要方法:
- 对完成了8次teprotumumab输注的患者进行了回顾性研究.
- 与治疗前和治疗后进行比较的proptosis测量 (毫米和百分比).
- 对回归时间的分析和对随访期间维持质减退的分析.
主要成果:
- 87.39%的眼睛显示了初始亡的改善.
- 65.38%的眼睛出现回归 (平均12.78%) 与治疗后的眼睛相比.
- 52.94%的回归发生在6个月内,有些病例持续恶化.
- 25.64%的眼睛在最近的随访中比治疗前有更多的proptosis.
- 63.46%的眼睛与治疗前相比保持了改善 (p < 0.001).
结论:
- 在teprotumumab治疗后的proptosis回归是常见的,通常发生在一年内,有些病例随着时间的推移而恶化.
- 尽管回归,但大多数患者与基线相比保持了降低的亡.
- 临床TED的持续时间没有影响回归的发生.
- 总的来说,与治疗前的水平相比,teprotumumab对降低proptosis产生了积极的净效应.
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