饮食的炎症潜力和状和腺状结肠直肠息肉的风险
L Beth Sung1, Helen G Coleman1, Nitin Shivappa2,3
1Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
Nutrition and cancer
|October 4, 2023
概括
通过能量调整的饮食炎症指数 (E-DIITM) 测量的一种促炎症饮食与结直肠腺瘤和超塑性息肉的风险增加有关. 推广抗炎饮食可能有助于预防结肠直肠多.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 预防癌症 预防癌症
背景情况:
- 关于结直肠癌前体的饮食炎症潜力还未得到充分研究,特别是状状病变 (SSLs).
- 能量调整的饮食炎症指数 (E-DIITM) 量化了抗炎和促炎饮食模式.
研究的目的:
- 调查E-DIITM与结直肠多的风险之间的关联,包括腺瘤,超塑性多和SSLs.
- 探索与参与者特征和炎症生物标志物的潜在相互作用.
主要方法:
- 美国的一项基于结肠镜的大型病例对照研究,涉及3246例对照和180例SSL病例,1530例腺瘤病例和472例多多病例.
- 后勤回归模型用于计算几率比率 (OR) 和95%置信区间 (CI).
- 根据参与者的特征和炎症生物标志物分层分析,包括尿性前列腺素E2代谢物 (PGE-M) 和高灵敏度血C反应蛋白 (hs-CRP).
主要成果:
- 最高的E-DIITM摄入量显著与结直肠腺瘤 (OR 1.36) 和超塑性息肉 (OR 1.43) 的风险增加有关.
- 对于SSL (OR 1.41) 观察到类似的,但不显著的风险增加 (OR 1.41).
- 这种关联在女性,正常体重的个体和具有较低基线炎症生物标志物水平 (PGE-M和hs-CRP) 的个体中更为强烈.
结论:
- 较高的E-DIITM得分,表明一种促炎饮食,与结直肠多的风险增加有关.
- 促进抗炎饮食模式可能是预防结肠直肠息肉的一种策略.
- 进一步研究饮食炎症和SSLS是有必要的.
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