林登四烯酸及其寡合物的化学和生物活性
Jun Luo1, Danyang Zhang1, Pengfei Tang1
1Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. cpu_lykong@126.com.
Natural product reports
|October 4, 2023
概括
林丹四烯酸 (LSs) 是各种各样的天然化合物,具有抗炎症,抗瘤和抗感染的特性. 本综述总结了它们的结构,合成和生物活性,从1925年到2023年.
科学领域:
- 自然产品化学 自然产品化学
- 有机合成 有机合成
- 药理学 药理学是指药理学的学科.
背景情况:
- 林登六二烯酸 (LSs) 是一类天然产品,其特点是独特的cis,trans-3,5,6-碳循环骨架.
- 在Lindera属和Chloranthaceae家族的植物中发现,LSs存在于单体和多种类型的寡体中.
- 自1925年以来,已经确定了354种天然LS及其寡合体,显示出显著的抗炎症,抗瘤和抗感染活性.
研究的目的:
- 从1925年到2023年7月,系统地审查关于林登石类 (LSs) 的研究.
- 提供LS结构,化学合成和生物活动的全面概述.
- 促进未来对LS及其寡合体的研究.
主要方法:
- 文学评论涵盖了1925年至2023年7月的出版物.
- 林登的系统分类 六方形结构和寡合物模式.
- 报告的化学合成策略和生物活性数据的摘要.
主要成果:
- 已发现超过354种天然的林登四烯酸 (LSs) 及其寡合物.
- 三分之二的LS是寡合体,通常通过Diels-Alder [4 + 2]循环加法形成,展示复杂的多环结构.
- LSs表现出一系列有价值的生物活性,包括抗炎,抗瘤和抗感染性质.
结论:
- 林登四烯酸 (LSs) 是天然产品化学的丰富领域,具有显著的治疗潜力.
- LSs的结构多样性和复杂架构,特别是它们的寡合物,为合成化学家带来了持续的挑战和机会.
- 这份综合性综述是促进LS及其寡合体的研究和应用的宝贵资源.
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