在体外皮肤模型的层次分析
Elizabeth Footner1,2, Kate Firipis1,2, Emily Liu1,2
1Electrical and Biomedical Engineering, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
ACS biomaterials science & engineering
|October 4, 2023
概括
先进的体外人体皮肤模型为药物开发和化品提供了精确的,无动物测试. 这些复杂的模型更好地复制本地皮肤功能,提高研究准确性和应用.
科学领域:
- 生物技术是生物技术.
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 在体外人体皮肤模型对于研究皮肤生物学和疾病至关重要.
- 这些模型越来越多地用于药物测试,安全评估和化品开发.
- 准确的体外模型减少了动物试验,并使得更精确,临床相关的研究.
研究的目的:
- 审查最近在体外人体皮肤模型方面的进展.
- 突出它们在各个领域的应用.
- 讨论当前的局限性和未来的研究方向.
主要方法:
- 关于用于皮肤模型开发的生物制造技术和生物材料的最新文献的综述.
- 复杂,多层次的皮肤模型的分析,包括功能性皮肤组件.
- 专注于模仿皮肤屏障,机械性能,色素,血管,毛囊,腺体和皮下层的模型.
主要成果:
- 复杂的体外皮肤模型的开发,这些皮肤模型非常接近本地人的皮肤.
- 纳入关键的功能组件,如皮肤屏障,血管和毛囊.
- 增强了细胞对细胞和细胞对物质相互作用的概述,以获得更大的生物相关性.
结论:
- 实验室人体皮肤模型正在快速发展,为替代动物试验提供了显著的潜力.
- 综合功能组件的复杂模型提供了更准确和临床相关的数据.
- 生物制造领域的持续创新有望进一步改善皮肤生物学和疾病的建模.
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