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Updated: Jul 15, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

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DNA不匹配修复保护基因组免受氧气诱导的复制性突变发生

Rita Lózsa1, Eszter Németh1, Judit Z Gervai1

  • 1Institute of Enzymology, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.

Nucleic acids research
|October 4, 2023
PubMed
概括

DNA不匹配修复 (MMR) 主要修复氧气诱导的DNA不匹配. 这项研究揭示了MMR.

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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