[患有潜在的类风湿性疾病的患者的关节置换结果]
Dominik Emanuel Holzapfel1, Max Thieme2, Tobias Kappenschneider2
1Medical Center, Department of Orthopaedic Surgery Asklepios Klinikum Bad Abbach, Regensburg University, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Deutschland. dominik.holzapfel@ukr.de.
Zeitschrift fur Rheumatologie
|October 4, 2023
概括
患有风湿性疾病 (RD) 的患者在全关节置换 (TJR) 后面临更高的术后并发症风险. 然而,RD患者获得了类似的结果,有些人在全膝关节置换 (TKR) 后表现出更好的结果.
科学领域:
- 整形外科和风湿病学
- 手术结果研究研究.
- 患者报告的结果衡量结果.
背景情况:
- 人工关节置换为晚期退行性关节疾病提供了显著的好处.
- 风湿性疾病 (RD) 在接受全关节置换 (TJR) 的患者中代表着复杂的并发症.
研究的目的:
- 评估潜在的风湿性疾病对术后并发症的影响.
- 评估患者在选择性全膝关节置换 (TKR) 和全关节置换 (THR) 后报告的结果 (PRO) 在有或没有RD的患者中.
主要方法:
- 对9149名接受选择性TKR或THR的患者进行了回顾性分析.
- 具有和没有RD的患者之间的并发症率和PRO的比较.
- 多变量后勤回归以确定 RD 作为并发症的独立风险因素.
主要成果:
- 患有RD的患者在TJR后出现了增加的医疗并发症 (7.1%对5.2%) 和严重的 (Clavien-Dindo IV级) 并发症 (2.8%对1.8%).
- 手术修复和手术并发症的发生率在各组之间是相似的 (2.5%对2.4%).
- 在TKR后的RD患者中观察到更高的PRO响应率 (91.9%与84.5%),而TKR结果相似 (93.4%与93.2%).
结论:
- 尽管手术后并发症率较高,但患有RD的患者在TJR1年后获得了相似的功能结果.
- 接受TKR的RD患者表现出更高的响应率,表明显著的益处.
- 关节置换是潜在的风湿性疾病患者的可行和有益的治疗选择,即使考虑到他们的脆弱性.
相关概念视频
Rheumatic Heart Disease III: Medical Management
11
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
11
Rheumatic Heart Disease I: Introduction
14
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
14
Rheumatic Heart Disease IV: Nursing Management
18
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
18
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K


