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主体遗传和肠道微生物群共同调节的血液生物化学指标
Xinwei Jiang1, Boxuan Zhang1, Fangren Lan1
1Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Applied microbiology and biotechnology
|October 4, 2023
概括
宿主基因和肠道微生物群共同调节血中的胆固醇和葡萄糖等生化指标. 确定了影响这些特征的关键基因和微生物群落,为家禽健康和新陈代谢提供了洞察力.
科学领域:
- 动物遗传学动物遗传学
- 微生物组研究 微生物组研究
- 代谢健康 代谢健康
背景情况:
- 血液生化指标对于评估动物的健康和代谢功能至关重要.
- 了解宿主遗传和肠道微生物群之间的相互作用对于优化牲畜特征至关重要.
研究的目的:
- 研究宿主基因和肠道微生物群对血液生化指标 (总胆固醇,LDL-CH,TG,HDL-CH,BG) 和的生长特征的贡献.
- 确定参与调节这些指标的候选基因和微生物种群.
主要方法:
- 206只雄的肠道微生物群的全基因组测序和16S rRNA测序.
- 血液生化指标和生长特征之间的表型和遗传相关性的分析.
- 遗传性和微生物性估计.
- 对宿主遗传学和微生物GWAS进行全基因组关联研究 (GWAS).
主要成果:
- 在胆固醇 (CHOL,LDL-CH) 和生长特征之间观察到显著的负相关性.
- 血液的生物化学指标由宿主遗传和肠道微生物群共同调节,具有不同的遗传性和微生物能力.
- 确定了候选基因 (例如,RAP2C,DOCK11,NTS,BOP1用于HDL-CH;GDPD5,DHDH,KCNIP1用于BG) 和微生物种群 (例如,RF39,Clostridia_UCG_014用于CHOL;Streptococcaceae用于TG).
- 宿主基因显著影响肠道微生物群的组成.
结论:
- 主体遗传和肠道微生物群相互作用,塑造血液的生物化学概况和的生长性能.
- 特定的基因和微生物群落在调节胆固醇,HDL-CH,BG和TG水平方面发挥着关键作用.
- 这些发现为基因改进和基于微生物群的策略提供了基础,以提高家禽的健康和生产力.
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