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在衰老期间,生物性别对人类骨肌肉转录组的影响
Xiaoyu Huang1, Mao Chen1, Ya Xiao1
1Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, China.
Biogerontology
|October 4, 2023
概括
生物性别显著影响骨肌肉衰老. 基因表达变化在男性和女性之间有所不同,影响新陈代谢,免疫透和肌肉纤维类型.
科学领域:
- 分子生物学分子生物学
- 老年学是指老年学的学科.
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 生物性别是影响生理过程的关键因素,包括衰老.
- 性别对衰老骨肌肉中的基因表达变化的特定影响仍然不完全理解.
- 了解这些特定于性别的变化对于有针对性的干预和治疗至关重要.
研究的目的:
- 为了研究生物性别对老化骨肌肉中的基因表达特征的影响.
- 确定受肌肉衰老影响的性别特异性分子通路和基因网络.
- 为了比较男性和女性骨肌之间的与年龄相关的基因表达模式.
主要方法:
- 使用了基因表达总量 (GEO) 数据库中的mRNA表达特征.
- 进行了差异表达分析和加权基因共同表达网络分析 (WGCNA).
- 进行基因组丰富分析并构建蛋白质-蛋白质相互作用网络.
主要成果:
- 在不同表达的基因和性别之间的丰富途径中观察到有限的重叠.
- 女人丰富的路径反映了老年人的路径,不论性别.
- 肌肉肌氨酸丝路径的调节下降,而TGF-β和ECM路径在两性都被调节上升.
- 在新陈代谢,蛋白质合成/降解,免疫细胞透和肌纤维相关基因集群中发现了显著的性别差异.
结论:
- 衰老的骨肌肉表现出生物性别之间的独特分子特征.
- 巨大的横向肌肉衰老的性别特定变化表明肌肉类型变化的潜在差异.
- 这些发现强调了考虑性别作为肌肉衰老研究和治疗策略中的变量的重要性.
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