头发皮质醇和内分泌大麻素在上腺瘤患者的测量:一个病例对照研究
Chrysoula Mytareli1, Fani Athanasouli1, Evangelia Andreadaki1
1Unit of Endocrinology, 1St Department of Internal Medicine, NKUA, Laikon General Hospital, 11527, Athens, Greece.
Hormones (Athens, Greece)
|October 4, 2023
概括
在患有上腺意外瘤 (AIs) 的患者中,头发内大麻素水平显著降低. 这表明,与头发皮质醇不同,头发内大麻素可以作为AI评估的生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 生物化学 生化学
背景情况:
- 内分泌大麻素 (ECs) 在调节下丘脑-垂体-上腺皮质 (HPA) 轴方面发挥作用.
- 关于EC和HPA轴的人类数据有限,特别是在上腺偶发性瘤 (AIs) 中.
研究的目的:
- 与对照组相比,分析AI患者的胺 (AEA) 和2-阿拉基多诺伊尔糖醇 (2-AG) 和皮质醇 (F) 的头发水平.
- 评估EC和皮质醇水平之间的关联以及AI患者的整体荷尔蒙特征.
主要方法:
- 招募了44名AI患者和44名对照患者.
- 测量了基底和后甲抑制试验 (ODST) 的激素水平.
- 使用液体染色学双重质谱法量化头发EC和皮质醇水平.
主要成果:
- 与对照组相比,AI患者的头发AEA和2-AG水平显著降低 (p < 0.001和p = 0.002).
- 在AI患者的可能自主分泌 (PACS) 亚组中观察到较低的EC水平.
- 头发AEA水平与ODST后的皮质醇水平呈负相关性 (r = -0.257,p = 0.033).
- 两组之间没有发现头发皮质醇水平的显著差异.
结论:
- 头发内大麻素测量可以作为评估上腺意外瘤患者的潜在生物标志物.
- 在这种情况下,头发皮质醇分析不是检测轻度高皮质醇血症的可靠诊断工具.
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