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在患有内高血压的患者中,通过扫描源光学一致性断层扫描和血管扫描测量的视觉神经头部变化
Hang Wang1, Le Cao1, William Robert Kwapong1
1Department of Neurology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, China.
Ophthalmology and therapy
|October 4, 2023
概括
内高血压 (IH) 会改变视神经头部 (ONH) 的结构和微血管结构. 这些变化与疾病严重程度和内压力相关,为IH进展提供了洞察力.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 内高血压 (IH) 可以导致视神经头部 (ONH) 的结构和微血管变化.
- 了解这些变化对于管理内脏病和保护视力至关重要.
研究的目的:
- 通过扫描源光学连贯性断层扫描 (SS-OCT) 和OCT血管学 (OCTA) 来调查IH患者的ONH中的结构和微血管变化.
- 评估这些ONH变化与临床特征之间的关联,包括弗里森得分和内压力.
主要方法:
- 使用SS-OCT/OCTA测量视觉盘形态,周状视网膜神经纤维层 (pRNFL),细胞内状层 (GCIPL),以及各种体 (NFLP,SVP,ICP,DCP) 中的微血管密度.
- 弗里森得分,视力敏度和内压力在61名IH患者和65名对照人群中进行了评估.
主要成果:
- 与对照组相比,患有IH的患者表现出较厚的prnfl和GCIPL,以及较大的ONH边缘面积.
- 微血管密度在NFLP增加,但在IH患者的SVP,ICP和DCP下降.
- 结构和微血管变化与IH组的弗里森得分和内压力有显著的相关性.
结论:
- 在IH患者中,ONH存在显著的结构和微血管变异.
- 这些ONH变化与弗里森分数和内压力有明显的相关性,提供了宝贵的临床见解.
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