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Updated: Jul 15, 2025

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在IgG4相关疾病中伊内比利祖马布的有效性和安全性:随机对照试验的协议

Cory Perugino1, Emma L Culver2, Arezou Khosroshahi3

  • 1Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Rheumatology and therapy
|October 4, 2023
PubMed
概括

MITIGATE试验调查了inebilizumab,一种B细胞消耗疗法,用于预防免疫球蛋白G4相关疾病 (IgG4-RD) 的爆发. 这项首次的研究旨在通过减少疾病爆发和治疗毒性来改善患者的治疗结果.

关键词:
抗CD19单克隆抗体的抗体.B细胞的枯竭导致B细胞的枯竭.临床试验临床试验是指临床试验的临床试验.在IgG4-RD的研究中,与IgG4相关的疾病伊内比利祖马布 (inebilizumab) 是一种药物试验设计试验设计.

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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