实施自我报告的免疫抑制坚持调查问卷,以选脏移植接受者在日常护理中的不坚持
Akhil Sharma1,2, Siddharth Verma2, Saeid Mirzai3
1Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Clinical transplantation
|October 4, 2023
概括
在临床访问中进行的自愿自我报告调查确定了患有免疫抑制不坚持的移植患者. 这种方法得到了很好的接受,这表明它在常规移植后护理中用于早期检测的实用性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植医学 移植医学 移植医学
- 患者坚持的研究研究.
背景情况:
- 针对免疫抑制的自我报告的坚持措施通常仅限于研究环境.
- 识别不坚持是长期移植成功的关键.
研究的目的:
- 评估一个自愿的,非匿名的自我报告措施在确定免疫抑制不遵守在常规移植诊所的有效性.
- 评估患者在诊所访问期间对使用此类措施的看法.
主要方法:
- 一个单一中心的研究涉及610名脏移植接受者.
- 使用巴塞尔评估对免疫抑制药物坚持量表 (BAASIS) 评估不坚持.
- 通过定制问卷收集患者的感知.
主要成果:
- 在485名完全响应者中,38%的人报告不遵守.
- 不坚持的患者更年轻,不太可能接受预防性移植,距离移植更远,并且经历了更多的拒绝.
- 自我报告的不坚持与更高的氨酸抑制剂变异性相关,但不检测捐赠者特异性抗体.
- 大多数患者 (92%) 感到舒适报告遵守,发现调查相关 (71%),并没有觉得它干扰了他们的访问 (88%).
结论:
- 在例行诊所访问期间使用的自我报告问卷可以在大量患者群体中识别免疫抑制不遵守.
- 该措施得到了患者的良好接受,表明其可用于临床整合的可行性.
- 将自我报告遵守措施纳入移植后护理可以促进早期识别和管理不遵守.
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