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蛋白质激酶PDK1的编舞及其多样化的基板舞伴

Alejandro E Leroux1, Ricardo M Biondi1

  • 1Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina.

The Biochemical journal
|October 4, 2023
PubMed
概括

蛋白激酶PDK1通过两个关键机制酸化AGC激酶:与Akt/PKB的同位化和基质对接. 它的形状灵活性和PIF-口袋相互作用对于精确的基质向和药物发现至关重要.

关键词:
在 AGC 激酶中,有 AGC 激酶在PDPK1中使用PDPK1.全osteric调节的调节.酸化/脱酸化的方法蛋白质构成的结构.蛋白质激酶调节蛋白质激酶调节

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