局部乙与局部德克斯潘醇用于治疗与乳腺癌放射治疗相关的急性放射性皮炎:一项随机双盲研究
Nagwa E Abd Elazim1, Sara M Awad1, Maha S El-Naggar2
1From the Department of Dermatology, Venereology and Andrology, Assiut University Hospital, Assiut, Egypt.
Dermatitis : contact, atopic, occupational, drug
|October 4, 2023
概括
局部使用的ectoin奶油在经过乳腺癌放射治疗后的急性放射性皮炎的管理中,与德克桑醇相比,表现出更高的疗效,减少疼痛和.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 辐射疗法 辐射疗法
背景情况:
- 放射性皮炎是乳腺癌放射治疗的常见并发症.
- 目前用于放射性皮肤炎的标准治疗方法在有效性方面缺乏共识.
研究的目的:
- 为了比较局部乙和德克桑醇在治疗急性放射性皮炎的疗效.
- 评估对辐射相关症状和生活质量的影响.
主要方法:
- 这是一项双盲随机研究,涉及50名乳腺癌患者.
- 患者在放射治疗期间和之后每天两次接受7%的ectoin奶油或5%的dexpanthenol奶油.
- 评估包括放射性皮肤炎等级,症状,不良事件和Skindex-16生活质量得分.
主要成果:
- 埃克托因和德克桑醇都有效预防严重的放射性皮肤炎 (≥G3).
- 与德克桑醇相比,埃克托因显示放射性皮肤炎等级,疼痛和明显较低.
- 使用ectoin导致与皮肤相关的生活质量较少受损.
结论:
- 局部使用的ectoin在放射性皮肤炎管理中比德克桑醇提供了临床益处.
- 放射治疗时间表是放射性皮肤炎持久性的独立预测指标.
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