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慢性炎症在心血管疾病和高血糖之间起着桥梁的作用

Qiang Zhang¹, Chunxi Wu², Ying Liu¹

¹Health Management Center, Chongqing General Hospital, Chongqing, China.

Metabolic syndrome and related disorders

|October 4, 2023

概括

慢性炎症将高血糖与心血管疾病 (CVD) 事件联系在一起. 高敏感性C反应蛋白 (hs-CRP) 的升高表明风险增加,其中HbA1c和LDL胆固醇是关键因素.

科学领域:

生物医学科学生物医学科学
心血管健康心血管健康
代谢障碍代谢障碍代谢障碍

背景情况:

慢性炎症与心血管疾病 (CVD) 和糖代谢有关.
炎症,高血糖和心血管疾病亚临床特征之间的确切关系需要进一步阐明.
识别与炎症状况相关的因素对于了解疾病进展至关重要.

研究的目的:

评估与炎症状态相关的亚临床心血管疾病事件和高血糖症.
为了确定与炎症状况相关的独立因素.

主要方法:

使用高灵敏度C反应蛋白 (hs-CRP) 评估的炎症状态.
估计的心血管疾病事件由动脉内膜介质厚度 (cIMT),动脉样硬化和斑块.
通过糖化血红蛋白 (HbA1c) 确定的高血糖症.
多变量线性回归分析确定了与hs-CRP水平相关的独立因素.

主要成果:

与正常血糖相比,糖尿病前期和糖尿病显著增加了cIMT加厚,动脉动脉样硬化和斑块的风险.
糖尿病对动脉样硬化和斑块的风险比糖尿病前期更高.
增加hs-CRP水平与cIMT加厚,动脉样硬化和斑块的更高患病率相关.
在HbA1c和hs-CRP水平之间观察到强烈的线性关系 (R2 = 0.8685).
hs-CRP的独立相关物包括男女的HbA1c和LDL胆固醇;此外,男性的TSH和女性的年龄.

结论:

慢性炎症是高血糖和心血管疾病事件之间的联系.
针对炎症和相关风险因素,如HbA1c,LDL胆固醇,TSH和年龄,可能有助于延迟动脉动脉的过程.

关键词:

动脉样硬化心血管疾病动脉内心介质的厚度动脉内心介质的厚度慢性炎症是一种慢性炎症.糖尿病糖尿病患者糖尿病患者糖化血红蛋白是什么糖化血红蛋白是什么在糖尿病前期,糖尿病前期.

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