脊椎关节炎中脱髓化疾病的发生率和预测因素:来自纵向队列研究的数据
Patricia Remalante-Rayco1,2, Adrian I Espiritu2,3, Yassir Daghistani1,4
1Schroeder Arthritis Institute, Toronto Western Hospital, Spondylitis Program, University Health Network, Toronto, ON, Canada.
Rheumatology (Oxford, England)
|October 4, 2023
概括
在脊椎关节炎 (SpA) 患者中脱髓化疾病 (DD) 的发生率较低,但在轴性SpA (axSpA) 中比牛皮关节炎 (PsA) 高. 吸烟,IBD和axSpA的诊断预测了DD的发展.
科学领域:
- 类风湿病学 类风湿病学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 脊椎关节炎 (SpA) 包含一组炎症性疾病.
- 脱素性疾病 (DD) 是一种影响中枢神经系统的神经系统疾病.
- 了解SPA和DD之间的相互作用对于患者管理至关重要.
研究的目的:
- 确定脊椎关节炎 (SpA) 患者中脱髓化疾病 (DD) 的发生率.
- 为了确定在SPA患者群体中预测DD发展的特定风险因素.
主要方法:
- 对轴性SPA (axSpA) 和牛皮关节炎 (PsA) 患者的纵向队列数据库的分析.
- 使用竞争性风险分析计算DD的发病率 (IRs).
- 考克斯回归 (Fine和Gray的方法) 的应用来识别DD预测因子.
主要成果:
- 在2260名SpA患者中观察到18个DDD事件,平均IR为每10万人年31个.
- 与PsA (0.13%) 相比,axSpA (1.30%) 的20年DD发生率更高.
- 发展DD的预测因素包括持续吸烟 (HR 2.918),axSpA诊断 (HR 8.790),以及炎症性肠病 (IBD) 的存在 (HR 5.698).
结论:
- 在SPA患者中,DD的总体发病率很低.
- 与PSA患者相比,轴性SPA患者的DD发病率较高.
- 在SpA中DD发展的关键预测因素是axSpA诊断,IBD和吸烟史.
相关概念视频
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11
Prevalence and Incidence
606
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
606
Longitudinal Studies
175
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
175
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
14
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
14


