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由人类GIPR拼接变体介导的信号传导的分子基础

Fenghui Zhao1,2, Kaini Hang3,4, Qingtong Zhou5,6

  • 1The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Proceedings of the National Academy of Sciences of the United States of America
|October 4, 2023
PubMed
概括

葡萄糖依赖型胰岛素型多受体 (GIPR) 的变异拼接变体通过占据连接体结合口袋来构成性地抑制其信号传递. 这些发现揭示了新形式的连接体独立偏差信号在代谢受体功能.

关键词:
有偏见的信号传输.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.葡萄糖依赖的胰岛素型多受体受体.连接体独立调制的调制.拼接的变种 拼接的变种

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