预防性抗生素的时间管理和皮肤间胆道干预后系统感染的怀疑
Hyunjae Im1,2, Seung-Young Oh2, Leerang Lim3
1Department of Critical Care Medicine, National Cancer Center, Goyang-si, Gyeonggi-do, Korea.
Journal of hepato-biliary-pancreatic sciences
|October 4, 2023
概括
在皮下胆道干预 (PBI) 前一小时内服用预防性抗生素可以显著降低全身感染的风险. 在服用抗生素前一个多小时给予抗生素会增加感染风险,这凸显了PBI抗生素预防的精确时间的重要性.
科学领域:
- 医疗干预 医疗干预
- 预防传染病 预防传染病
- 胃肠病学 胃肠病学
背景情况:
- 目前的指导方针建议在经皮胆道干预 (PBI) 之前使用预防性抗生素.
- 关于PBI抗生素时间的证据主要基于手术数据.
- 对于PBI预防性抗生素的最佳时间尚不清楚.
研究的目的:
- 评估预防性抗生素时间对PBI后系统性感染发病率的影响.
- 为了确定在PBI之前给予抗生素的最佳窗口.
主要方法:
- 在PBI之前的四个抗生素给药时间间隔中比较感染率.
- 根据定义的临床标准,评估涉嫌的干预后系统性感染.
主要成果:
- 在454个PBI中,21.6%导致了可疑的全身感染.
- 在时间组之间观察到感染发病率的显著差异 (p=.020).
- 在PBI前1小时服用抗生素是感染的独立风险因素 (aOR=10.54).
结论:
- 在PBI前一小时内服用预防性抗生素与较低的感染率有关.
- 预防性抗生素的准确时间对于预防PBI后的全身感染至关重要.
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