为了更精确的预后分层在肝硬化急性去补偿:帕多瓦模型2.0
Alberto Zanetto1,2, Filippo Pelizzaro1,2, Monica Maria Mion3
1Gastroenterology and Multivisceral Transplant Unit, Azienda Ospedale - Università Padova, Padova, Italy.
United European gastroenterology journal
|October 4, 2023
概括
在急性不补偿性肝硬化 (AD) 中,前素 (PSP) 水平升高,可以预测急性至慢性肝衰竭 (ACLF) 的发展. 这种生物标志物可以改善AD患者的风险分层.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 生物标志物研究 生物标志物研究
- 关键护理医学 关键护理医学
背景情况:
- 急性不补偿性肝硬化 (AD) 呈现出异质的临床过程.
- 前素 (PSP) 是一个反映系统性炎症和Toll类受体活性的生物标志物.
研究的目的:
- 为了测量AD患者的PSP水平.
- 评估PSP对AD患者急性至慢性肝衰竭 (ACLF) 的预测价值.
主要方法:
- 预期招募173名阿尔茨海默病患者和对照组.
- 在入学时确定PSP水平.
- 一年后续评估ACLF的发展和预测因素.
主要成果:
- 与对照组相比,AD患者的PSP水平显著更高 (p < 0.001).
- 在AD患者中,较高的PSP水平与儿童-皮格C阶段和急性损伤有关.
- PSP,CLIF-C AD评分和Child-Pugh阶段是ACLF的独立预测因素. 帕多瓦模型2.0在识别高风险患者方面表现出高准确度 (AUROC 0.864).
结论:
- 纳入PSP的帕多瓦模型2.0有效地识别了患有ACLF高风险的AD患者.
- 在等待外部验证的情况下,PSP显示出作为改进AD风险分层的新生物标志物的潜力.
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