埃斯凯特胺鼻雾剂与奎蒂亚平用于治疗耐药抑郁症
Andreas Reif1, Istvan Bitter1, Jozefien Buyze1
1From the Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital, Goethe University Frankfurt, and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt (A.R.), Danuvius Klinik, Technische Universität München, Pfaffenhofen an der Ilm (T.M.), and Janssen Germany (K.C.) and Janssen EMEA (C.H.), Neuss - all in Germany; the Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary (I.B.); Janssen Pharmaceutica (J.B.) and Janssen EMEA (Y.K.) - both in Beerse, Belgium; the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna (R.F.); Janssen Research and Development, New Jersey (D.-J.F.); Janssen EMEA, High Wycombe (T.I.), the Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham (A.H.Y.) - all in the United Kingdom; CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, UMR 6602 Institut Pascal, Clermont-Ferrand (P.-M.L.), and Janssen EMEA, Paris (B.R.) - both in France; Champalimaud Research and Clinical Center, Champalimaud Foundation, and NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa - both in Lisbon, Portugal (A.J.O.-M.); Janssen EMEA, Dublin (S.M.-H.); and Janssen EMEA, Sofia, Bulgaria (Y.G.).
在与SSRI/SNRIs结合使用时,Esketamine鼻喷剂在治疗耐药抑郁症中的缓解率高于奎胺. 这项研究突出了对患有持续抑郁症状的患者有前途的新治疗方案.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 耐治疗抑郁症 (TRD) 的特点是缓解率低,复发率高.
- 目前对TRD的治疗选择有效性有限.
- 对于TRD,埃斯基坦胺鼻喷剂和奎平的比较有效性尚未得到充分证实.
研究的目的:
- 为了比较埃斯基坦胺鼻喷剂与延长释放氨酸作为TRD患者的增强疗法的疗效.
- 评估TRD患者的缓解率和复发预防,这些患者在与SSRI/SNRIs一起接受治疗,并服用乙胺或乙胺.
主要方法:
- 一个3b期,随机,主控试验,涉及TRD患者.
- 患者接受了埃斯基坦胺鼻喷剂或延长释放氨酸,两者与SSRI或SNRI相结合.
- 主要终点是第8周的缓解,定义为蒙哥马利-阿斯伯格抑郁评分表 (MADRS) 评分≤10.
主要成果:
- 埃斯凯他鼻雾剂在第8周的缓解率显著更高 (27.1%),相比于奎蒂亚平 (17.6%).
- 在获得缓解后的第32周内,接受胺胺治疗的患者较少出现复发.
- 副作用与两种治疗方法已知的安全性概况一致.
结论:
- 在与SSRI/SNRIs结合使用时,Esketamine鼻喷剂在TRD患者的缓解方面优于延长释放类奎胺.
- 与奎平相比,埃斯凯特胺鼻喷剂代表了TRD更有效的增强策略.
相关概念视频
Antidepressant Drugs: MAOIs and Other Agents
Psychosis: Goals of Pharmacotherapy
Electroconvulsive Therapy
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Psychosis and Antipsychotic Drugs: Overview


