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在接触体育运动运动员脑脊液中错误折叠的α-Synuclein

Anna Vasilevskaya^1,2,3, Ivan Martinez-Valbuena¹, Chloe Anastassiadis^1,2,3

¹Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Movement disorders : official journal of the Movement Disorder Society

|October 4, 2023

概括

错误折叠的α-synuclein (α-synuclein) 在20%使用脑脊液 (CSF) RT-QuIC的前运动员中被检测到. 阳性与特定大脑区域灰质减少相关,这表明它可能是早期帕金森病的生物标志物.

科学领域:

神经科学是一个神经科学.
生物标志物发现发现
神经退行性疾病神经退行性疾病

背景情况:

错误折叠的α-synuclein (α-synuclein) 是帕金森病 (PD) 和具有勒维体 (DLB) 的痴呆症的标志.
实时震动诱导转换 (RT-QuIC) 技术可以检测脑脊液 (CSF) 中错误折叠的α-synuclein.

研究的目的:

为了确定前运动员中错误折叠的CSFα-synuclein的发生率.
为了比较α-synuclein阳性和阴性前运动员之间的临床,体育史,大脑体积和生物标志物数据.

主要方法:

使用RT-QuIC分析了30名前运动员的脑脊髓液中的α-synuclein.
评估了临床表现,体育史,脑体积通过MRI,以及CSF生物标志物 (p-tau,t-tau,Aβ42,NfL).

主要成果:

六名前运动员 (20%) 的测试结果为错误折叠的CSFα-synuclein呈阳性.
与α-Synuclein阳性运动员相比,与阴性运动员相比,α-Synuclein阳性运动员在人口统计,运动史或CSF生物标志物方面没有显著差异.
然而,α-synuclein阳性运动员在右下轨道前皮层,右前皮层和右嗅觉皮层中表现出较少的灰质体积.

结论:

脑液α-synuclein RT-QuIC阳性可能成为帕金森病和勒维体痴呆症的早期,突发性生物标志物.
这些发现突出了运动史,α-synuclein聚合和脑缩的特定模式之间的潜在联系.

关键词:

这是帕金森氏症.运动员运动员运动员脑震荡是一次脑震荡.一个 α 合成核蛋白.

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