在慢性高发性痛风患者中增加结肠癌的风险:基于人口的研究
Antoine Boustany1, Romy Rahhal2, Jad Mitri3
1Department of Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Arquivos de gastroenterologia
|October 4, 2023
概括
患有慢性甲状腺痛风的患者患结直肠癌 (CRC) 的风险显著增加. 这项研究强调痛风是CRC的独立风险因素,强调需要主动查和管理.
科学领域:
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 是美国癌症死亡的主要原因,已确立的危险因素包括吸烟,酒精,肥胖和2型糖尿病.
- 血清尿酸水平升高以前与癌症相关的多和其他癌症有关,这表明与CRC的潜在联系.
研究的目的:
- 调查慢性多发性痛风与患结直肠癌的风险之间的关联.
- 在调整了混变量后,确定慢性形痛风是否是结直肠癌的独立风险因素.
主要方法:
- 使用来自360多家美国医院的经过验证的多中心数据库进行了回顾性队列分析.
- 包括成年患者 (18岁以上),但不包括家族腺瘤多重症,结肠癌家族史和炎症性肠病.
- 使用多变量回归分析来计算结直肠癌的风险,并调整潜在的混因素.
主要成果:
- 该研究分析了来自70177200人的数据,在结直肠癌组中发现了2型糖尿病,吸烟,肥胖,酒和慢性甲状腺痛风的更高患病率.
- 多变量分析显示,男性 (OR: 1.02),吸烟者 (OR: 1.54),酒者 (OR: 1.40),肥胖患者 (OR: 1.52),2型糖尿病患者 (OR: 3.53) 和慢性甲状腺痛风患者 (OR: 1.40;95% CI: 2.48-3.23) 的结直肠癌风险增加具有统计学意义.
- 患有慢性甲状腺痛风病史的患者患结直肠癌的风险显著增加,即使考虑到代谢风险因素.
结论:
- 与没有痛风的患者相比,慢性甲状腺痛风患者的结直肠癌患病率明显高,独立于其他代谢风险因素.
- 这些发现表明,慢性甲状腺痛风是结直肠癌的独立风险因素.
- 需要进一步的研究来探索血清尿酸控制对痛风患者的影响,以潜在地减轻结肠直肠癌风险.
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