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Updated: Jul 15, 2025

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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突变TSC2蛋白在线粒分裂中的非正规功能

Mary-Bronwen L Chalkley1, Rachel B Mersfelder1, Maria Sundberg2

  • 1Department of Cell & Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.

PloS one
|October 4, 2023
PubMed
概括

结核性硬化综合体 (TSC) 涉及TSC1/TSC2基因的突变,影响mTORC1信号传递. 研究人员在TSC2突变细胞中发现了一种新的多极细胞分裂缺陷,独立于mTORC1抑制,揭示了新的疾病机制.

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