在患有状细胞疾病的儿童和青少年中,鼻吸气流的峰值:一个病例对照研究
Ana Karine Vieira1, Cristina Gonçalves Alvim2, Clara Polito Braga2
1Hemominas Foundation, Master's Degree in Pediatrics - Belo Horizonte (MG), Brazil.
概括
患有状细胞疾病的儿童通常会减少鼻腔吸气流的峰值,这表明可能存在上呼吸道阻塞. 这种简单的测试可以帮助临床查受影响的个体.
科学领域:
- 儿科血液学 儿科血液学
- 呼吸系统医学 呼吸系统医学
- 遗传学 遗传学 是一个
背景情况:
- 状细胞病 (SCD) 是一种常见的遗传性血液疾病,具有广泛的健康影响.
- 上呼吸道阻塞,特别是腺突增大,是SCD患者经常出现的并发症.
- 峰鼻吸气流 (PNIF) 是对上呼吸道功能的非侵入性测量.
研究的目的:
- 评估被诊断患有状细胞疾病 (SCD) 的儿科患者的峰值鼻吸气流 (PNIF).
- 通过PNIF测量SCD和上呼吸道功能减弱之间的关系.
主要方法:
- 一项涉及279名8至15岁儿童和青少年的病例控制研究.
- 在93名患有SCD的儿童 (病例) 和186名健康儿童 (对照组) 之间的PNIF测量结果的比较.
主要成果:
- 与对照组相比,患有SCD的儿童具有较低PNIF值的可能性显著更高 (82.83%).
- 75%的SCD患者表现出较低范围的PNIF值,而对照组只有25%.
结论:
- 减少PNIF在患有状细胞疾病的儿童中非常普遍.
- 测量PNIF可以作为一个有价值的查工具在日常临床评估儿科SCD患者检测上呼吸道阻塞.
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