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Updated: Jun 14, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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一个人性化化基因系统抑制了与鼠类疼痛相关的行为和人类感官神经元中的过度活动

Jimena Perez-Sanchez1, Steven J Middleton1, Luke A Pattison2

  • 1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Science translational medicine
|October 4, 2023
PubMed
概括

一个新的化学遗传系统,PSAM4-GlyR,有效地沉默感官神经元的过度兴奋性,为治疗神经病痛等持续性疼痛条件提供了一个有希望的途径.

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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...