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科罗拉多州儿童中侵袭性A组链球菌的爆发,2022年10月至2023年4月
Erin C Ho1,2, Jessica R Cataldi1,2, Lori J Silveira1
1Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Journal of the Pediatric Infectious Diseases Society
|October 4, 2023
概括
2022年,科罗拉多州的儿科侵袭性A组链球菌 (iGAS) 住院病例显著增加. 这次疫情出现了更严重的病例,可能与并发的病毒性呼吸道感染有关.
科学领域:
- 微生物学 微生物学
- 儿童传染病 儿童传染病
- 流行病学 流行病学
背景情况:
- 在2022年秋季期间,科罗拉多州的儿科入侵性A组链球菌 (iGAS) 住院病例急剧增加.
- 启动了对这次疫情的比较研究,将其与前几年的iGAS流行病学,临床特征和患者结局进行比较.
研究的目的:
- 为了将科罗拉多州在2022-2023年期间发生的小儿侵袭性A组链球菌 (iGAS) 爆发的流行病学,临床特征和结果与历史数据进行比较.
- 确定与儿童严重iGAS疾病相关的潜在风险因素和临床指标.
主要方法:
- 从2022年10月到2023年4月,在住院儿科患者中前性地确定和审查了96例IGAS病例.
- 回溯分析了三个时期的无菌部位GAS阳性培养物:COVID-19前,大流行和疫情爆发,并比较了每月病例数.
主要成果:
- 疫情爆发期间 (9.9例/月) 与大流行前水平 (3.9例/月) 相比,几乎增加了三倍.
- 相关的病毒呼吸道症状存在于近60%的病例中. 39%的患者需要重症监护,四名患者死亡.
- 与大流行前和大流行期间相比,爆发病例的肺炎 (28%) 和多焦点疾病 (17%) 率显著更高.
结论:
- 侵袭性A组链球菌 (iGAS) 爆发病例数量几乎是大流行前基线的三倍.
- 相关病毒症状的高发病率表明与并发的呼吸道病毒激增有联系.
- 早期识别重症儿童可能有助于识别严重IGAS的特定临床和实验室特征.
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