心理困扰和DNA甲基化的关联:5年纵向基于人口的双胞胎研究
Xuanming Hong1,2, Ke Miao1,2, Weihua Cao1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Psychiatry and clinical neurosciences
|October 4, 2023
概括
随着时间的推移,心理困扰 (PD) 可能会导致DNA甲基化 (DNAm) 的变化. 这项研究在中国双胞胎种群中确定并验证了与PD相关的DNA甲基化位点,为PD分子机制提供了洞察力.
科学领域:
- 遗传学和表观遗传学
- 精神病学和心理健康 精神病学和心理健康
- 分子生物学分子生物学
背景情况:
- 心理困扰 (PD) 是一个重要的心理健康问题.
- 基因甲基化 (DNAm) 在基因调节中起着至关重要的作用,并与各种健康状况有关.
- 了解PD的分子基础对于开发有效的干预措施至关重要.
研究的目的:
- 确定与心理困扰 (PD) 相关的特定的5'-酸-瓜宁-3'位点 (CpG).
- 研究DNA甲基化 (DNAm) 和PD的动态变化之间的时间关系.
- 在中国双胞胎队列中验证先前识别的PD相关CpG.
主要方法:
- 全表观基因组关联研究 (EWAS) 对来自中国国家双胞胎登记册 (CNTR) 的1084名双胞胎进行了研究,数据收集于2013年和2018年.
- 使用PubMed,Embase和EWAS目录的数据进行了之前报告的PD相关CpG的验证.
- 一项交叉滞后分析检查了308名完成两项调查的双胞胎的DNAm变化和PD之间的时间性.
主要成果:
- 该研究通过EWAS确定了25种与PD相关的新型CpG.
- 验证分析证实了101个先前报告的CpG与PD相关,错误发现率<0.05.
- 交叉滞后分析显示,在14个CpG时,PD与DNAm之间存在单向关联,表明PD可能在DNA甲基化变化之前发生.
结论:
- 这项研究成功地在中国双胞胎人口中识别和验证了PD相关的CPG.
- 这些发现表明,心理困扰在推动DNA甲基化随时间推移的变化方面可能起到潜在的因果作用.
- 这项研究有助于更深入地了解涉及心理痛苦病理生理学的分子机制.
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