缺失牙数量与所有原因和心血管疾病死亡率之间的关联:NHANES 1999-2004年和2009-2014年
Ruming Shen1, Shuaijie Chen1, Jiayi Shen1
1Lishui Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Journal of periodontology
|October 4, 2023
概括
失去牙与死亡风险增加有关,特别是心血管死亡. 这种风险随着缺失的牙增加到10个,然后是平原,在年轻人中更为明显.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 牙健康 牙健康
背景情况:
- 牙脱落和死亡率之间的关系需要进一步研究.
- 失去牙可以作为整体健康状况的指标.
研究的目的:
- 调查牙脱落与全因和心血管死亡率之间的关联.
- 探索这种关联中潜在的非线性关系和与年龄相关的差异.
主要方法:
- 利用了1999-2014年国家健康和营养检查调查 (NHANES) 17993名参与者的数据.
- 采用加权多变量Cox比例危险模型和限制立方线 (RCS) 来分析死亡风险.
- 评估了缺失牙数量与死亡率结果之间的关联,考虑年龄作为一个因素.
主要成果:
- 平均116个月的随访显示2,152人死亡,其中625人死于心血管疾病.
- 缺少11-19颗牙的参与者表现出所有原因死亡的最高风险 (HR 1.89),而6-10颗缺失的牙表明心血管死亡的最高风险 (HR 2.51).
- 观察到非线性,反转的L形关联;死亡风险增加了多达10颗缺失的牙,但没有进一步升级,与年龄有显著的相互作用.
结论:
- 牙损失与死亡率呈现反转的L形关联,风险增加至10颗缺失的牙.
- 牙脱落和死亡率之间的关联在65岁以下的成年人中更为强烈.
- 这些发现强调了牙损失作为增加死亡风险的潜在标志物,特别是心血管死亡率.
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