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Updated: Jul 15, 2025

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
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新型Siglec-7子的合成和结合模式预测

Martin Frank1,2, Elena Kuhfeldt3, Jonathan Cramer4

  • 1Molecular Structure Analysis Core Facility-W160, German Cancer Research Center, 69120 Heidelberg, Germany.

Journal of medicinal chemistry
|October 4, 2023
PubMed
概括

研究人员发现了新的酸衍生物,它们与Siglec-7结合,这是一个关键的免疫细胞调节器. 分子动力学模拟揭示了新的结合相互作用,并突出了设计Siglec-7抑制剂的力场限制.

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