艾滋病毒感染者的C型肝炎治疗:消除疾病和不平等的潜力
Oluwaseun Falade-Nwulia1, Catherine R Lesko2, Anthony T Fojo3
1Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
The Journal of infectious diseases
|October 4, 2023
概括
直接作用抗病毒药物 (DAA) 在患有人类免疫缺陷病毒 (PWH) 的人群中显著降低了C型肝炎病毒 (HCV) 病毒症. 针对性干预仍然对使用毒品的PWH至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 肝炎C病毒 (HCV) 感染对患有人类免疫缺陷病毒 (PWH) 的人来说是一个重大问题.
- 直接作用抗病毒药物 (DAA) 已经彻底改变了HCV治疗.
- 了解PWH中HCV病毒性趋势对于公共卫生战略至关重要.
研究的目的:
- 评估直接作用抗病毒药物 (DAA) 对型肝炎病毒 (HCV) 病毒病流行率的人类免疫缺陷病毒 (PWH) 的影响.
- 确定与DAA时代之前和之后的HCV病毒病相关的人口和行为因素.
主要方法:
- 在3755名患有人类免疫缺陷病毒 (PWH) 的人群中,对HCV病毒病患率的回顾性分析.
- 在DAA前 (2009) 和DAA时代 (2021) 的HCV病毒病率的比较.
- 统计分析以确定与HCV病毒病相关的因素.
主要成果:
- 在PWH中,HCV病毒病发病率下降了94.0%,从2009年的36%降至2021年的2%.
- 与HCV病毒病相关的因素在2009年从男性性别,黑人种族和年龄较大转移到两个时代的注射药物使用.
- 注射药物使用仍然是HCV病毒病的重要风险因素.
结论:
- 直接作用抗病毒药物 (DAA) 在患有人体免疫缺陷病毒 (PWH) 的人群中大大降低了HCV病毒性.
- 虽然人口统计学已经发生了变化,但注射药物使用仍然是HCV病毒病的关键因素.
- 有针对性的干预措施对于解决正在使用药物的PWH持续的HCV护理需求至关重要.
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