一个新的基于废水的流行病学工作流程,以使用制药代理数据估计社区范围的非传染性疾病流行率
Nicola Ceolotto1, Patricia Dollamore2, Angus Hold2
1Department of Chemistry, University of Bath, Bath BA2 7AY, UK; Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Bath BA2 7AY, UK; Institute for Sustainability, University of Bath, Bath BA2 7AY, UK.
Journal of hazardous materials
|October 4, 2023
概括
本研究介绍了一种基于废水的新型流行病学 (WBE) 工作流程,以使用制药生物标志物估计非传染性疾病 (NCD) 的患病率. 经过验证的方法从废水数据准确评估药物使用和疾病趋势.
科学领域:
- 环境化学环境化学
- 公共卫生 公共卫生
- 分析化学 分析化学
背景情况:
- 非传染性疾病 (NCD) 构成了全球健康的重大负担.
- 目前用于NCD流行率估计的方法通常依赖于自我报告的数据或临床记录,这些数据可能是有限的.
- 基于废水的流行病学 (WBE) 为人口层面的健康监测提供了一个有希望的补充方法.
研究的目的:
- 开发和验证基于废水的综合性流行病学工作流程,以估计非传染性疾病的流行率.
- 利用药物及其代谢物作为NCDs的生物标志物.
- 为公共卫生中WBE应用建立标准化和强大的方法.
主要方法:
- 选择了83种目标分析物 (54种药物和29种代谢物).
- 优化和验证固相提取 - 超高性能液体染色学和并联质谱法 (SPE-UHPLC-MS/MS) 的方法.
- 在各种储存条件下评估分析物的稳定性,并将人类新陈代谢数据纳入精确的后续计算.
主要成果:
- 大多数分析物的高稳定性被观察到,只有少数例外.
- 分析物的回收率一般在75%至125%之间,方法检测和量化极限较低.
- 经过验证的方法表现出高准确度 (99.5%) 和精度 (4.0%),使得69个NCD目标的每日使用率可以估计.
结论:
- 开发的WBE工作流提供了一种可靠和标准化的方法来估计NCD流行率.
- 这种方法可以准确评估药物使用情况,并可与处方数据进行比较.
- WBE是公共卫生监测和了解人口健康趋势的宝贵工具.
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