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在100°C的中性水溶液中 (2R,3R) -二米瑞的热降解

Haolin Zhang¹, Shiye Lin², Ruiwei Xie³

¹Institute of Chinese Medical Sciences, University of Macau, Macau.

|October 4, 2023

概括

在水中的二米瑞 (DMY) 的热降解产生各种化合物,包括酸. 热处理减少了DMY的抗氧化活性和对肠道微生物群的有益作用.

科学领域:

食品化学食品化学
自然产品化学自然产品化学
分析化学分析化学

背景情况:

黄类热降解研究主要集中在黄类,对二黄类的关注有限.
二黄具有独特的C2-C3单键,与黄的C2-C3双键相比,可能导致不同的降解途径.
具有显著健康益处的二黄 (dihydroflavonol) - - 迪米瑞 (DMY) 尚未在水溶液中的热降解方面进行广泛研究.

研究的目的:

在100°C的中性水溶液中研究二米瑞 (DMY) 的热降解途径.
确定和描述在热处理过程中形成的DMY的降解产物.
了解热降解对DMY稳定性,抗氧化活性以及对肠道微生物群的影响.

主要方法:

在100°C的中性水溶液 (pH7) 中进行了DMY的热降解.
超高性能液体色谱与光二极管阵列和电喷离子四极点飞行时间联质谱检测 (UPLC-PDA-ESI-QTOF-MS/MS) 结合使用了分析.
负离子模式被用于质谱检测,以识别降解产物和中间体.

主要成果:

对DMY进行热处理,导致DMY度随时间变化而下降,并形成许多降解产物.
已识别的降解机制包括异构化,氧化,基化,二氧化和环裂变,提出B环的初始氧化和随后的二氧化.
关键的中间体和主要的最终产品,包括四种酸 (例如3,4,5-三基酸) 和其他化合物,被确定并以其质量-电荷比和保留时间来表征.

结论:

该研究阐明了水溶液中二米瑞的新型热降解途径,突出了其在热下的不稳定性.
热降解显著降低了DMY的抗氧化活性及其对肠道微生物群组成的积极影响.
这些发现为DMY的稳定性及其在涉及热处理的应用中的潜在局限性提供了关键的见解.

关键词:

这是一种二米里西丁 (dihydromyricetin).迪默 (Dimer) 是一个数字.热量热量热量热量氧化的方法是氧化过程中的氧化.环切裂纹是指环切裂纹.

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