2型糖尿病中更多的新癌症与糖尿病足病:一项纵向观察性研究
Fadi Alkhami1, Gauthier Borderie1, Ninon Foussard1
1Bordeaux CHU and University, Endocrinology-Diabetology-Nutrition, 33000, Bordeaux, France.
Diabetes & metabolic syndrome
|October 4, 2023
概括
糖尿病足病在2型糖尿病 (T2D) 患者中显著增加癌症风险,几乎使得患新癌症的可能性增加了一倍. 这凸显了在T2D中管理足部健康对于预防癌症的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 糖尿病学 糖尿病学
背景情况:
- 2型糖尿病 (T2D) 与癌症死亡率的增加有关.
- 糖尿病足病 (DFD) 是T2D的严重并发症,预期寿命缩短.
- 需要调查DFD与随后癌症发展之间的关联.
研究的目的:
- 调查糖尿病足病与2型糖尿病患者患新癌症的风险之间的关系.
- 确定DFD是否是T2D患者癌症的独立风险因素.
主要方法:
- 在2009-2017年期间住院的519名T2D患者的回顾性队列分析.
- 基于糖尿病脚风险的分层 (糖尿病脚分类国际工作组).
- 多变量考克斯回归和生存分析,以评估与DFD相关的癌症风险.
主要成果:
- 27%的患者患有DFD;159人被归类为有风险 (1或2级).
- 在54个月的随访期间,诊断出63种 (12.1%) 新癌症.
- 基线DFD与癌症风险增加两倍显著相关 (aHR:2.08,95%CI:1.02-4.25).
结论:
- 糖尿病足病与2型糖尿病患者患新癌症的风险显著增加有关.
- 这项研究表明,在T2D患者群体中,DFD和瘤发生之间存在潜在的联系.
- 需要进一步的研究来阐明这种关联背后的机制.
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